APC derived from donor splenocytes support retinal autoimmune disease in allogeneic recipients

Journal of Leukocyte Biology

Dale S. Gregerson¹  Hidetoshi Kawashima¹ 

[1] Department of Ophthalmology, University of Minnesota, MinneapolisDepartment of Ophthalmology, University of Minnesota, MinneapolisDepartment of Ophthalmology, University of Minnesota, Minneapolis

关键词: autoimmunity;    antigen presentation;    arrestin;    uveoretinitis;    T cells;   

DOI  :  10.1189/jlb.0404249

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

T cell adoptive transfer models of autoimmune disease have been used in conjunction with radiation/bone marrow chimeras to define the minimal requirements for antigen (Ag) recognition. In models with central nervous system Ags, major histocompatibility complex (MHC) class II compatibility achieved by grafting F1 bone marrow into parental recipients was reported to be necessary and sufficient for transfer of CD4 T cell-mediated experimental autoimmune encephalomyelitis. Bone marrow-derived, perivascular microglia are now widely regarded to play a critical role in the expression of experimental autoimmune diseases of the nervous system. Similar results might be expected in the experimental autoimmune uveoretinitis model, as retina is an extension of the brain. Using an allogeneic Ag-presenting cell (APC) adoptive transfer strategy, it was found that resident APC were not essential and that their replacement with MHC-compatible cells by bone marrow-grafting techniques was not necessary. Instead, APC were recruited from the circulation.

【 授权许可】

Unknown