Regulation of TLR signaling and inflammation by SOCS family proteins

Journal of Leukocyte Biology

Akihiko Yoshimura¹  Toshikatsu Hanada¹  Daisuke Aki¹  Hiroyuki Mori Masanobu Ohishi¹ 

[1] Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, JapanDivision of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, JapanDivision of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

关键词: cytokine;    tyrosine kinase;    Toll-like receptor;    STAT;    NF-κB;    inflammatory bowel disease;    rheumatoid antithesis;    endotoxin;   

DOI  :  10.1189/jlb.0403194

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. These cytokines exert their biological functions through Janus tyrosine kinases and signal transducer and activator of transcription factors. The cytokine-inducible Src homology 2 protein (CIS) and suppressors of cytokine signaling (SOCS) are a family of intracellular proteins, several of which have emerged as key physiological regulators of cytokine responses, including those that regulate the inflammatory systems. In this short review, we focused on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in Toll-like receptor signal regulation and inflammatory diseases.

【 授权许可】

Unknown