Interferon-γ: an overview of signals, mechanisms and functions

Journal of Leukocyte Biology

Kate Schroder²  Timothy Ravasi²  Paul J. Hertzog¹  David A. Hume² 

[1] CRC for Chronic Inflammatory Diseases, Parkville, Victoria, Australia; and Molecular Genetics Group, Institute of Reproduction and Development, Monash Medical Centre, Monash University, Clayton, Victoria, Australia CRC for Chronic Inflammatory Diseases, Parkville, Victoria, Australia; and CRC for Chronic Inflammatory Diseases, Parkville, Victoria, Australia; and Molecular Genetics Group, Institute of Reproduction and Development, Monash Medical Centre, Monash University, Clayton, Victoria, Australia Molecular Genetics Group, Institute of Reproduction and Development, Monash Medical Centre, Monash University, Clayton, Victoria, Australia CRC for Chronic Inflammatory Diseases, Parkville, Victoria, Australia; and Molecular Genetics Group, Institute of Reproduction and Development, Monash Medical Centre, Monash University, Clayton, Victoria, Australia;Institute for Molecular Bioscience, University of Queensland, St. Lucia, Brisbane, Australia; CRC for Chronic Inflammatory Diseases, Parkville, Victoria, Australia; and Institute for Molecular Bioscience, University of Queensland, St. Lucia, Brisbane, Australia; Institute for Molecular Bioscience, University of Queensland, St. Lucia, Brisbane, Australia; CRC for Chronic Inflammatory Diseases, Parkville, Victoria, Australia; and CRC for Chronic Inflammatory Diseases, Parkville, Victoria, Australia; and Institute for Molecular Bioscience, University of Queensland, St. Lucia, Brisbane, Australia; CRC for Chronic Inflammatory Diseases, Parkville, Victoria, Australia; and

关键词: macrophage;    cytokine;    lipopolysaccharide;    Toll-like receptor;    inflammation;   

DOI  :  10.1189/jlb.0603252

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Interferon-γ (IFN-γ) coordinates a diverse array of cellular programs through transcriptional regulation of immunologically relevant genes. This article reviews the current understanding of IFN-γ ligand, receptor, signal transduction, and cellular effects with a focus on macrophage responses and to a lesser extent, responses from other cell types that influence macrophage function during infection. The current model for IFN-γ signal transduction is discussed, as well as signal regulation and factors conferring signal specificity. Cellular effects of IFN-γ are described, including up-regulation of pathogen recognition, antigen processing and presentation, the antiviral state, inhibition of cellular proliferation and effects on apoptosis, activation of microbicidal effector functions, immunomodulation, and leukocyte trafficking. In addition, integration of signaling and response with other cytokines and pathogen-associated molecular patterns, such as tumor necrosis factor-α, interleukin-4, type I IFNs, and lipopolysaccharide are discussed.

【 授权许可】

Unknown