Alerting and tuning the immune response by extracellular nucleotides

Journal of Leukocyte Biology

Andrea la Sala¹  Marco Idzko⁴  Johannes Norgauer⁴  Davide Ferrari²  Giampiero Girolomoni³  Francesco Di Virgilio² 

[1] Immune Cell Interaction Unit, Mucosal Immunity Section, Laboratory of Clinical Investigation, NIAID, National Institutes of Health, Bethesda, Maryland; Immune Cell Interaction Unit, Mucosal Immunity Section, Laboratory of Clinical Investigation, NIAID, National Institutes of Health, Bethesda, Maryland; Immune Cell Interaction Unit, Mucosal Immunity Section, Laboratory of Clinical Investigation, NIAID, National Institutes of Health, Bethesda, Maryland;Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation (ICSI), University of Ferrara, Italy; Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation (ICSI), University of Ferrara, Italy; Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation (ICSI), University of Ferrara, Italy;;Laboratory of Immunology, Istituto Dermopatico dell’Immacolata, IRCCS, Rome, Italy Laboratory of Immunology, Istituto Dermopatico dell’Immacolata, IRCCS, Rome, Italy Laboratory of Immunology, Istituto Dermopatico dell’Immacolata, IRCCS, Rome, Italy;Department of Experimental Dermatology, University of Freiburg, Germany; and Department of Experimental Dermatology, University of Freiburg, Germany; and Department of Experimental Dermatology, University of Freiburg, Germany; and

关键词: dendritic cell;    monocyte;    ATP;    chemokine;    IL-12;   

DOI  :  10.1189/jlb.0802418

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

The interplay between pro- and anti-inflammatory mechanisms during inflammatory and immune responses is critical for avoiding excessive tissue damage. Extracellular nucleotides (e.g., adenosine 5′-triphosphate) may represent constitutive signals that can alert the immune system of abnormal cell death. Relatively high doses of nucleotides induce rapid release of proinflammatory mediators and favor pathogen killing. However, recent findings on antigen presenting cells, particularly dendritic cells, revealed a more complex role for these molecules. Chronic exposure to low-dose nucleotides can redirect cellular responses to prototypic activation stimuli, leading to suppressed inflammation and immune deviation.

【 授权许可】

Unknown