Age-associated increase of basal corticosterone levels decreases ED2high, NF-κBhigh activated macrophages

Journal of Leukocyte Biology

Nobuo Matsuura⁶  Yoshinobu Ohira²  Takako Kizaki⁷  Naoki Maruyama³  Hideki Ohno⁷  Noorbibi K. Day⁴  Robert A. Good⁴  Kazunori Onoé⁵  Tomomi Ookawara⁸  Shukoh Haga¹  Kazuya Iwabuchi⁵ 

[1] #Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaragi; #Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaragi; #Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaragi;;Department of Hygiene, National Defense Medical College, Tokorozawa, Saitama; ††Department of Physiology and Biomechanics, National Institute of Fitness and Sports, Kanoya, Kagoshima, Japan; and Department of Hygiene, National Defense Medical College, Tokorozawa, Saitama; Department of Hygiene, National Defense Medical College, Tokorozawa, Saitama; ††Department of Physiology and Biomechanics, National Institute of Fitness and Sports, Kanoya, Kagoshima, Japan; and ††Department of Physiology and Biomechanics, National Institute of Fitness and Sports, Kanoya, Kagoshima, Japan; and Department of Hygiene, National Defense Medical College, Tokorozawa, Saitama; ††Department of Physiology and Biomechanics, National Institute of Fitness and Sports, Kanoya, Kagoshima, Japan; andDepartment of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo; Department of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo; Department of Molecular Pathology, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo;;Department of Pediatrics, All Children’s Hospital, St. Petersburg, Florida Department of Pediatrics, All Children’s Hospital, St. Petersburg, Florida Department of Pediatrics, All Children’s Hospital, St. Petersburg, FloridaSection of Pathology, Institute of Immunological Science, Hokkaido University, Sapporo, Hokkaido; Section of Pathology, Institute of Immunological Science, Hokkaido University, Sapporo, Hokkaido; Section of Pathology, Institute of Immunological Science, Hokkaido University, Sapporo, Hokkaido;Department of Hygiene, Kyorin University, School of Medicine, Mitaka, Tokyo; Department of Pediatrics, School of Medicine, Kitasato University, Sagamihara, Kanagawa; Department of Hygiene, Kyorin University, School of Medicine, Mitaka, Tokyo; Department of Hygiene, Kyorin University, School of Medicine, Mitaka, Tokyo; Department of Pediatrics, School of Medicine, Kitasato University, Sagamihara, Kanagawa; Department of Pediatrics, School of Medicine, Kitasato University, Sagamihara, Kanagawa; Department of Hygiene, Kyorin University, School of Medicine, Mitaka, Tokyo; Department of Pediatrics, School of Medicine, Kitasato University, Sagamihara, Kanagawa;Department of Hygiene, Kyorin University, School of Medicine, Mitaka, Tokyo; Department of Hygiene, Kyorin University, School of Medicine, Mitaka, Tokyo; Department of Hygiene, Kyorin University, School of Medicine, Mitaka, Tokyo;Department of Hygiene, National Defense Medical College, Tokorozawa, Saitama; Department of Hygiene, National Defense Medical College, Tokorozawa, Saitama; Department of Hygiene, National Defense Medical College, Tokorozawa, Saitama;

关键词: antigen presentation;    cytokines;    transcription factors;    immunomodulators;   

DOI  :  

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

The proportion of cells with a high density of ED2 (ED2high cells) in peritoneal cells from old rats was significantly lower than that from young rats. The expression of major histocompatibility complex class II (MHC class II) molecules, the antigen presentation, production of interleukin (IL)-1β and IL-6, and nuclear factor-κB activity in ED2high cells were markedly higher than those in cells with a low density of ED2 (ED2low cells), although no significant difference was observed in the expression of MHC class II molecules and the antigen presentation between ED2high cells from young and old rats. Meanwhile, basal corticosterone concentration in serum and glucocorticoid (GC) receptor mRNA expression in peritoneal cells increased significantly in old rats. The proportion of ED2high cells was increased by adrenalectomy in young rats. Furthermore, nuclear translocation of GC receptor was observed in ED2low cells, whereas GC receptor was detected in cytoplasmic extracts from ED2high cells. These results suggest that the decrease in functional ED2high macrophages with age results in the age-associated decline of immune responses, which is regulated, in part, by the basal GC concentration.

【 授权许可】

Unknown