Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells

Journal of Leukocyte Biology

Joost J. Oppenheim¹  Oleg Chertov²  De Yang¹  Qian Chen¹ 

[1]Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Laboratory of Molecular Immunoregulation, Division of Basic Sciences, Laboratory of Molecular Immunoregulation, Division of Basic Sciences,

[2]Intramural Research Support Program, SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland Intramural Research Support Program, SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland Intramural Research Support Program, SAIC Frederick, National Cancer Institute-Frederick Cancer Research and Development Center, Frederick, Maryland

关键词: α-defensins;    chemotaxis;    T lymphocytes;   

DOI  :  

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Defensins, a family of cationic, structurally related, antimicrobial peptides, contribute to host defense by disrupting the cytoplasmic membrane of microbes. Here we show that human neutrophil defensins selectively induce the migration of human CD4+/CD45RA+ naive and CD8+, but not CD4+/CD45RO+ memory, T cells. Moreover, human neutrophil defensins are chemotactic for immature human dendritic cells derived from either CD34+ progenitors or peripheral blood monocytes. Upon maturation induced by treatment with tumor necrosis factor α (TNF-α), dendritic cells lose their responsiveness to human neutrophil defensins. The chemotactic effect of human neutrophil defensins on both T and dendritic cells is pertussis toxin-sensitive, suggesting that a Giα protein-coupled receptor is responsible. Human neutrophil defensins are also chemotactic for immature murine dendritic cells. These data suggest that, in addition to their antimicrobial role, human neutrophil defensins also contribute to adaptive immunity by mobilizing T cells and dendritic cells.

【 授权许可】

Unknown