Diuretic Renal Scintigraphy in Patients with Sulfonamide Allergies: Possible Alternative Use of Ethacrynic Acid

Journal of Nuclear Medicine Technology

Ba D. Nguyen¹  Ming Yang¹  Jason Robert Young¹  Michael C. Roarke¹  Howard H. Osborn¹ 

关键词: ethacrynic acid;    diuretic renal scintigraphy;    sulfonamide allergy;   

DOI  :  10.2967/jnmt.115.161331

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Furosemide may trigger life-threatening sulfonamide cross-hypersensitivity reactions, posing a dilemma in patients who need diuretic renal scintigraphy. Methods: We present our experience using ethacrynic acid as a nonsulfonamide alternative diuretic in 5 patients, with a discussion of the diuretic molecular structure, potential side effects, protocol development, and imaging results. Results: Diuretic renal scintigraphy using ethacrynic acid provided useful information about the obstruction status in all patients, with no adverse clinical impact. Conclusion: Ethacrynic acid is a potential alternative to furosemide for patients with severe sulfonamide reactions.

【 授权许可】

Unknown