Evaluation of Patients with Head and Neck Cancer by Means of 99mTc-Glucarate

Journal of Nuclear Medicine Technology

Lucía Delgado¹  Martín Lafferranderie¹  Omar Alonso¹  Javier Noble¹  Juan P. Gambini¹  Ricardo D'Albora¹  Margarita Nuñez¹  Eduardo Corchs¹  Eduardo Savio¹  Pablo Cabral¹ 

关键词: head and neck tumors;    ^99mTc-glucarate;    SPECT/CT software fusion;   

DOI  :  10.2967/jnmt.109.062927

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Preliminary findings have suggested that 99mTc-glucarate has tumor-seeking properties. The purpose of this study was to explore the potential of this tracer to evaluate malignant head and neck tumors by means of SPECT/CT software fusion imaging. Methods: Eleven male patients with advanced head and neck carcinoma were included in the study: 9 with locally advanced disease and 2 with clinical suspicion of local relapse. Scanning started 3–6 h after the injection of 1,110 MBq of 99mTc-glucarate. Planar and SPECT images of the head, neck, and thorax were acquired. Three-dimensional images were also coregistered with CT. Results: We found 99mTc-glucarate uptake in all suspected lesions. SPECT/CT fusion imaging was helpful in all cases for topographically localizing the tracer foci. Conclusion: 99mTc-glucarate can be considered a potential tracer for the evaluation of patients with head and neck tumors.

【 授权许可】

Unknown