Comparison of Methods of Attenuation and Scatter Correction in Brain Perfusion SPECT

Journal of Nuclear Medicine Technology

Masayasu Takeuchi¹  Jun Deguchi¹  Isamu Narabayashi¹  Keita Utsunomiya¹  Masuo Hayashi¹  Makoto Yamada¹  Tsuyoshi Komori¹  Kensei Kanna¹ 

关键词: brain perfusion SPECT;    autoradiography method;    stable XeCT regional CBF measurement;    scatter correction;    attenuation correction;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Objective: The radioactivity count distribution in the brain must be determined accurately to accurately measure cerebral blood flow (CBF). Scatter and attenuation are factors that compromise the accuracy of determining radioactivity counts in the brain.Methods: We compared regional CBF in patients by an autoradiographic method using N-isopropyl-p-[123I] iodoamphetamine when, first, attenuation correction alone was performed uniformly on SPECT images by using empiric μ-values (Chang method); second, scatter correction was performed and the μ-values of a homogeneous-attenuation body of water were used for attenuation correction (triple-energy window [TEW] + Chang method); and third, scatter correction was performed and the μ-values calculated by CT were used for attenuation correction (TEW + CT method). We also compared regional CBF measured by these methods with the values obtained by the xenon CT/CBF method, which uses CT and stable xenon.Results: Scatter correction reduced overestimation of regional CBF in low-flow regions. The TEW + CT method yielded better regional and overall correlations with the xenon CT/CBF method than did either of the other methods.Conclusion: The TEW + CT method of correction gave the most accurate measurements of regional CBF.

【 授权许可】

Unknown