Impact of Patient Motion on Myocardial Perfusion SPECT Diagnostic Integrity: Part 2

Journal of Nuclear Medicine Technology

Geoffrey M. Currie¹  Janelle M. Wheat¹ 

[1] School of Clinical Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia School of Clinical Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia School of Clinical Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia

关键词: patient motion;    incidence;    myocardial perfusion SPECT;    motion artifacts;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Objective:Advances in 99mTc-based radiopharmaceuticals and multiple-detector gantries have the potential to increase the significance of patient motion on the diagnostic integrity of myocardial perfusion SPECT acquisitions.Methods:An experimental study was used to evaluate the effect of various patient motions on the diagnostic integrity of myocardial perfusion SPECT data using 522 motion simulations generated from a technically and diagnostically normal dataset.Results:Of studies with induced motion, 21.7% of simulated motion demonstrated motion-induced artifacts. Abrupt motion resulted in artifacts for 52.6% of studies, whereas bounce motion resulted in artifacts in 6.8% of studies. The locations where motion resulted in the most studies with artifacts were at 45° (36.1%) and 75° (32.4%). No statistical difference was demonstrated between single, dual-, and triple-head configurations.Conclusion:Combining these results with those of the clinical evaluation of incidence indicates that patient motion during 99mTc-based myocardial perfusion SPECT studies is a potential source of false-positive findings for coronary artery disease. There is a 7.1% probability that myocardial perfusion SPECT studies performed at the 3 sites investigated will contain a motion-induced artifact. Fully realized, this potential results in decreased test specificity and unfavorable cost and consequence outcomes.

【 授权许可】

Unknown