Testing Different Storage Conditions for 99mTc-MAG3 Kit: Can Hot Fractioning Reduce the Cost per Unit Dose?

Journal of Nuclear Medicine Technology

Bilge Volkan Salancı¹  Pınar Özgen Kıratlı¹ 

[1] Department of Nuclear Medicine, Hacettepe University Medical Center, Ankara, Turkey Department of Nuclear Medicine, Hacettepe University Medical Center, Ankara, Turkey Department of Nuclear Medicine, Hacettepe University Medical Center, Ankara, Turkey

关键词: ^99mTc-MAG3;    cost reduction;    fractioning;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Since its release for routine clinical use, 99mTc-mercaptoacetyltriglycine (MAG3) has become an important alternative to 131I-labeled orthoiodohippuran. The cold kit for MAG3 is expensive, especially in developing countries. Therefore, unique storage conditions should be provided for cost reduction. Cold fractioning is a well-known procedure but has special requirements, such as a nitrogen tank and a laminar flow hood. The aim of this study was to prolong the shelf life of 99mTc-labeled MAG3 by a hot fractioning method, which separates the patient doses after 99mTc labeling. The radiochemical purity of the 99mTc-labeled MAG3 kit was tested under different storage conditions. Hot fractioning of the 99mTc-labeled MAG3 kit was found to be a possible alternative to cold fractioning for routine clinical studies.

【 授权许可】

Unknown