Rapid Quality Control of Technetium-99m-Tetrofosmin: Comparison of Miniaturized and Standard Chromatography Systems

Journal of Nuclear Medicine Technology

A. Michael Zimmer¹  Robert C. Hendel¹  Stewart M. Spies¹  William G. Spies¹  Monica C. Geyer¹ 

[1] Section of Nuclear Cardiology, Department of Nuclear Medicine, Northwestern University Medical Center, Chicago, Illinois Section of Nuclear Cardiology, Department of Nuclear Medicine, Northwestern University Medical Center, Chicago, Illinois Section of Nuclear Cardiology, Department of Nuclear Medicine, Northwestern University Medical Center, Chicago, Illinois

关键词: technetium-99m-tetrofosmin;    radiochemical purity testing;    miniaturized chromatography system;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Objective: In this paper, we evaluate the use of miniaturized ITLC-SG strips (10 cm x 1 cm) with the same solvent system of methylene chloride:acetone (65:35) to reduce the time required to perform the quality control procedure for 99mTc-tetrofosmin. The potential problems inherent in the standard chromatography system were investigated as to the magnitude of their effects on the miniaturized system.Methods: The migration of the radiochemical components of 99mTc-tetrofosmin was evaluated using multiple miniature and standard strip sizes. Following optimization of the miniaturized system, radiochemical purity evaluations were performed simultaneously on 112 99mTc-tetrofosmin preparations using both chromatography systems and the radiochemical purity results compared.Results: Initially, similar migration of radiochemical components was found using both chromatography systems. Results of the radiochemical purity evaluations of 99mTc-tetrofosmin preparations were similar with both chromatography methods, with a mean difference of 1.3% ± 1.5%. Differences in radiochemical purity results between the two chromatography systems were less than 2% in the majority of samples. In no instance was a preparation acceptable with one chromatography system and not acceptable with the other.Conclusion: The results indicate that the miniaturized chromatography system is as effective in evaluating the radiochemical purity of 99mTc-tetrofosmin as the standard quality control procedure, with a substantial reduction in the time required to perform the procedure.

【 授权许可】

Unknown