In Vivo Comparison of Anticoagulant Citrate Dextrose Versus Heparin for Use as an Anticoagulant with the UltraTag® Red Blood Cell Kit

Journal of Nuclear Medicine Technology

Mark W. Gebhard¹  Brian P. Mullan¹  Joseph C. Hung¹  Joseph F. Wieseler¹  Mark E. Wilson¹ 

[1] Mayo Clinic, Rochester, Minnesota Mayo Clinic, Rochester, Minnesota Mayo Clinic, Rochester, Minnesota

关键词: technetium-99m;    red blood cells;    UltraTag^® RBC kit;    anticoagulant;   

DOI  :  

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Objective: The package insert for the UltraTag® RBC kit recommends the use of either heparin or anticoagulant citrate dextrose (ACD) as an anticoagulant. A comparison study between heparin and ACD solution was done to assess image quality.Methods: Fourteen patients’ red blood cells (RBC) were labeled with the UltraTag® RBC kit and 99mTc using 10 units of heparin or 0.15 ml of ACD solution-A per ml of blood. The labeling efficiency (LE) of the 99mTc-labeled RBC was determined before and after reinjection, and multigated acquisition (MUGA) and whole-body images were subsequently obtained.Results: The images were analyzed by comparing the heart-to-background ratio, heart-to-lung ratio and kidney-to-background ratio. Both heparin and ACD gave similar LE and ratios of regions of interest.Conclusion: There was no significant difference between ACD and heparin groups in overall image quality either on MUGA or on visual inspection of whole-body images.

【 授权许可】

Unknown