Transgenic Fatal Familial Insomnia Mice Indicate Prion Infectivity-Independent Mechanisms of Pathogenesis and Phenotypic Expression of Disease

PLOS Pathogens

Laura Tapella¹  Cinzia Bisighini¹  Galina V. Beznoussenko¹  Susanna Mantovani¹  Claudia Balducci¹  Luca Imeri¹  Fabio Fiordaliso¹  Liliana Comerio¹  Alessandra Paladini¹  Ihssane Bouybayoune¹  Ilaria Bertani¹  Roberto Chiesa¹  Federico Del Gallo¹  Fabrizio Tagliavini¹  Elena Restelli¹  Joaquín Castilla¹  Natalia Fernández-Borges¹  Gianluigi Forloni¹  Francesca Baracchi¹  Michela Mangieri¹  Edoardo Micotti¹ 

关键词: Sleep;    Mouse models;    Fatal familial insomnia;    Mice;    Electroencephalography;    Neurons;    Animal prion diseases;    Prion diseases;   

DOI  :  10.1371/journal.ppat.1004796

学科分类：生物科学（综合）

来源: Public Library of Science

【 授权许可】

Unknown