Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous System

PLOS Pathogens

Alain Le Coupanec¹  Mathieu Dubé¹  Nabil G. Seidah¹  Marc Desforges¹  Mathieu Meessen-Pinard¹  Pierre J. Talbot¹  Robert Day¹ 

关键词: Central nervous system;    Neurovirulence;    Coronaviruses;    Virus glycoproteins;    Microbial mutation;    Mouse models;    Cell cultures;    Viral diseases;   

DOI  :  10.1371/journal.ppat.1005261

学科分类：生物科学（综合）

来源: Public Library of Science

【 授权许可】

Unknown