Identification of the Mechanisms Causing Reversion to Virulence in an Attenuated SARS-CoV for the Design of a Genetically Stable Vaccine

PLOS Pathogens

Jose M. Jimenez-Guardeño¹  Luis Enjuanes¹  Jose A. Regla-Nava¹  Marta L. DeDiego¹  Raul Fernandez-Delgado¹  Carlos Castaño-Rodriguez¹  Stanley Perlman¹  Jose L. Nieto-Torres¹ 

关键词: SARS coronavirus;    Recombinant proteins;    Sequence motif analysis;    Cell cultures;    Attenuated vaccines;    Plasmid construction;    Protein domains;    Microbial mutation;   

DOI  :  10.1371/journal.ppat.1005215

学科分类：生物科学（综合）

来源: Public Library of Science

【 授权许可】

Unknown