Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni

PLOS Pathogens

Marina Moraes Mourão¹  Karin Schmidtkunz¹  Martin Marek¹  Guilherme Oliveira¹  Vincent Cura¹  Wolfgang Sippl¹  Manfred Jung¹  Jean Cavarelli¹  Julien Lancelot¹  Luiza Andrade¹  Alexander-Thomas Hauser¹  Stéphanie Caby¹  Christophe Romier¹  Jean-Paul Renaud¹  Srinivasaraghavan Kannan¹  Diana A. Stolfa¹  Raymond J. Pierce¹ 

关键词: Schistosoma;    Parasitic diseases;    Schistosoma mansoni;    Enzyme structure;    Phenylalanine;    Zinc;    Enzyme inhibitors;    Epigenetics;   

DOI  :  10.1371/journal.ppat.1003645

学科分类：生物科学（综合）

来源: Public Library of Science

【 授权许可】

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