Gain-of-Sensitivity Mutations in a Trim5-Resistant Primary Isolate of Pathogenic SIV Identify Two Independent Conserved Determinants of Trim5α Specificity

PLOS Pathogens

Ruchi M. Newman¹  Andrea Kirmaier¹  Aaron G. Schmidt¹  Welkin E. Johnson¹  Allison L. Wyand¹  Kevin R. McCarthy¹ 

关键词: HIV-1;    Viral packaging;    Primates;    Macaque;    Viral evolution;    Amino acid substitution;    Substitution mutation;    HIV-2;   

DOI  :  10.1371/journal.ppat.1003352

学科分类：生物科学（综合）

来源: Public Library of Science

【 授权许可】

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