Early Low-Titer Neutralizing Antibodies Impede HIV-1 Replication and Select for Virus Escape

PLOS Pathogens

Alan S. Perelson¹  Peter D. Kwong¹  Beatrice H. Hahn¹  William Fischer¹  Jason S. McLellan¹  David C. Montefiori¹  Yongping Yang¹  Barton F. Haynes¹  Peter Hraber¹  Shilpa S. Iyer¹  Vitaly V. Ganusov¹  Katharine J. Bar¹  Ivelin Georgiev¹  Kwan-Ki Hwang¹  Hui Li¹  Jeffrey W. Pavlicek¹  Mattia Bonsignori¹  Julie M. Decker¹  Shuyi Wang¹  George M. Shaw¹  Sarah Sterrett¹  Xi Chen¹  Brandon F. Keele¹  Hua-Xin Liao¹  Chun-yen Tsao¹  Feng Gao¹  Bette T. Korber¹ 

关键词: HIV-1;    Microbial mutation;    Sequence alignment;    Antibodies;    Viral replication;    Amino acid sequence analysis;    Sequence motif analysis;    Polymerase chain reaction;   

DOI  :  10.1371/journal.ppat.1002721

学科分类：生物科学（综合）

来源: Public Library of Science

【 授权许可】

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