A Multi-Step Process of Viral Adaptation to a Mutagenic Nucleoside Analogue by Modulation of Transition Types Leads to Extinction-Escape

PLOS Pathogens

Ignacio de la Higuera¹  Esteban Domingo¹  Armando Arias¹  Celia Perales¹  Nuria Verdaguer¹  Rosa Pérez-Luque¹  Rubén Agudo¹  Cristina Ferrer-Orta¹ 

关键词: Polymerases;    Substitution mutation;    Microbial mutation;    Amino acid substitution;    Cloning;    Nucleotide sequencing;    RNA structure;    Viral replication;   

DOI  :  10.1371/journal.ppat.1001072

学科分类：生物科学（综合）

来源: Public Library of Science

【 授权许可】

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