Clinical and hepatic evaluation in adult dengue patients: a prospective two-month cohort study

Revista da Sociedade Brasileira de Medicina Tropical

Zagne, Sônia Maria Oliveira¹  Amin, Beatriz¹  Fazoli, Flávia¹  Zagne, Luiza Oliveira¹  Centro de Referência de Dengue, Campos dos Goytacazes¹  Tristão-Sá, Ricardo¹  Universidade Federal do Mato Grosso do Sul, Campo Grande¹  Universidade Federal do Espírito Santo, Vitória¹  Zandonade, Eliana¹  Fundação Oswaldo Cruz, Rio de Janeiro¹  Cruz, Oswaldo Gonçalves¹  Nascimento, Delso do¹  Rocha, Natally de Souza Maciel¹  Nogueira, Rita Maria Ribeiro¹  Cunha, Rivaldo Venâncio da¹  Kubelka, Claire Fernandes¹  Escola Superior de Ciências, Vitória¹  Souza, Luiz José de¹  Instituto Oswaldo Cruz, Rio de Janeiro¹  Universidade Federal Fluminense, Niterói¹  Froes, Íris Bucher¹  Araújo, Nathália Félix¹ 

关键词: Dengue;    Hepatic dysfunction;    Persistence of symptoms;    Prospective cohort;   

DOI  :  10.1590/S0037-86822012000600004

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

INTRODUCTION: To analyze the liver dysfunction and evolution of signs and symptoms in adult dengue patients during a two-month follow-up period.METHODS: A prospective cohort study was conducted in Campos dos Goytacazes, Rio de Janeiro, Brazil, from January to July, 2008. The evolution of laboratory and clinical manifestations of 90 adult dengue patients was evaluated in five scheduled visits within a two-month follow-up period. Twenty controls were enrolled for the analysis of liver function. Patients with hepatitis B, hepatitis C, those known to be human immunodeficiency virus (HIV) seropositive and pregnant women were excluded from the study.RESULTS: At the end of the second month following diagnosis, we observed that symptoms persisted in 33.3% (30/90) of dengue patients. We also observed that, 57.7% (15/26) of the symptoms persisted at the end of the second month. The most persistent symptoms were arthralgia, fatigue, weakness, adynamia, anorexia, taste alteration, and hair loss. Prior dengue virus (DENV) infection did not predispose patients to a longer duration of symptoms. Among hepatic functions, transaminases had the most remarkable elevation and in some cases remained elevated up to the second month after the disease onset. Alanine aminotransferase (ALT) levels overcame aspartate aminotransferase (AST) during the convalescent period. Male patients were more severely affected than females.CONCLUSIONS: Dengue fever may present a wide number of symptoms and elevated liver transaminases at the end of the second month.

【 授权许可】

Unknown