Prevalence of hepatitis B virus infection and carriage after nineteen years of vaccination program in the Western Brazilian Amazon

Revista da Sociedade Brasileira de Medicina Tropical

Borges, Fabiane Giovanella¹  Braga, Wornei Silva Miranda¹  Martinho, Ana Cristina de Souza¹  Scazufca, Márcia¹  Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus¹  Universidade do Estado do Amazonas, Manaus¹  Menezes, Paulo Rossi¹  Azevedo, Eliete Pereira de¹  Rodrigues, Ivo Seixas¹  Castilho, Márcia da Costa¹  Universidadede São Paulo, São Paulo¹ 

关键词: HBV;    Hepatitis B;    Prevalence;    Vaccination;    Epidemiology;   

DOI  :  10.1590/S0037-86822012000100004

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

INTRODUCTION: Reductions in the prevalence of hepatitis B virus (HBV) infection and carriage, decreases in liver cancer incidence, and changes in patterns of liver dysfunctions are described after hepatitis B vaccination.METHODS: We conducted a population-based seroprevalence study aimed at estimating the HBV prevalence and risk of infection in the rural area of Lábrea following nineteen years of HBV vaccination.RESULTS: Half of the subjects showed total anti-HBc of 52.1% (95% CI 49.6-54.7). The HBsAg prevalence was 6.2% (95% CI 5.1-7.6). Multivariate analysis showed an inverse association between HBV infection and vaccination (OR 0.62; 95% CI 0.44-0.87). HBsAg remained independently associated with past hepatitis (OR 2.44; 95% CI 1.52-3.89) and inversely to vaccination (OR 0.43; 95% CI 0.27-0.69). The prevalence of HBeAg among HBsAg-positive individuals was 20.4% (95% CI 12.8-30.1), with the positive subjects having a median age of 11 years (1-46) p=0.0003.CONCLUSIONS: We demonstrate that HBV infection is still an important public health issue and that HBV vaccination could have had better impact on HBV epidemiology. If we extrapolate these findings to other rural areas in the Brazilian Amazon, we can predict that the sources of chronic infected patients remain a challenge. Future studies are needed regarding clinical aspects, molecular epidemiology, surveillance of acute cases, and risk groups.

【 授权许可】

Unknown