Nutritional assessment and lipid profile in HIV-infected children and adolescents treated with highly active antiretroviral therapy

Revista da Sociedade Brasileira de Medicina Tropical

Universidade de São Paulo, Ribeirão Preto¹  Negrini, Bento Vidal de Moura¹  Monteiro, Jacqueline Pontes¹  Sartorelli, Daniela Saes¹  Tremeschin, Marina Hjertquist¹  Cervi, Maria Célia¹  Salomão, Roberta Garcia¹ 

关键词: Body composition;    Dyslipidemia;    Highly active antiretroviral therapy;    HIV- positive children;    Lipid profile;    Nutritional status;   

DOI  :  10.1590/S0037-86822011005000039

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

INTRODUCTION: HIV-infected children and adolescents treated with highly active antiretroviral therapy (HAART) regimens that include a protease inhibitor (PI) can show significant improvements in clinical outcomes, nutritional status and quality of life. The study aimed to report nutritional and metabolic alterations for pediatric patients continuously exposed to HAART and for healthy controls for up to 1 year.METHODS: Clinical, anthropometric, lipid profile and food intake data were collected prospectively over approximately 12-months for each patient.RESULTS: Fifty-one individuals were studied, of these, 16 were healthy. After 12 months follow-up, HIV-positive individuals remained below the healthy control group parameters. No change was observed concerning food intake. Triglyceride serum levels were higher in patients using protease inhibitor at the onset of the study [PI groups: 114 (43 - 336), and 136 (63 - 271) versus control group: 54.5 (20 - 162); p = 0.003], but after twelve months follow-up, only the group using protease inhibitor for up to two months presented higher values [140 (73 - 273) versus 67.5 (33 - 117); p = 0.004]. HDL-cholesterol was lower in HIV-positive individuals [HIV-positive groups: 36 (27 - 58) and 36 (23 - 43); control 49.5 (34 - 69); p = 0.004].CONCLUSIONS: HIV-infected children and adolescents treated with highly active antiretroviral therapy showed compromised nutritional parameters compared to a paired healthy control group. Individuals using protease inhibitor presented worse triglyceride serum levels compared to their healthy counterparts.

【 授权许可】

Unknown