Adverse reactions in Chagas disease patients treated with benznidazole, in the State of Ceará

Revista da Sociedade Brasileira de Medicina Tropical

Coêlho, Ivo Castelo Branco¹  Dias, Aparecida Tiemi Nagao¹  Coelho, Helena Lutéscia Luna¹  Pontes, Vânia Maria Oliveira de¹  Universidade Federal do Ceará, Fortaleza¹  Oliveira, Maria de Fátima¹  Universidade Federal do Ceará Fortaleza¹  Cruz, Francisco Marcondes Tavares da¹  Souza Júnior, Alcidésio Sales de¹  Hospital Universitário Walter Cantídio, Fortaleza¹ 

关键词: Chagas disease;    Trypanosoma cruzi;    Benznidazole;    Adverse reactions to drugs;   

DOI  :  10.1590/S0037-86822010000200015

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

INTRODUCTION: Chagas disease is caused by Trypanosoma cruzi and treated with benznidazole (BNZ). This drug has the troublesome features of presenting partial effectiveness and high toxicity ranging from hypersensitivity reactions to medullary aplasia. The objective here was to describe and evaluate the occurrence of adverse reactions in Chagas disease patients treated with benznidazole in Fortaleza, Ceará.METHODS: This was a prospective descriptive study involving 32 chronic Chagas patients treated with benznidazole between January 2005 and April 2006. Sociodemographic and clinical data were collected through questionnaires, interviews and laboratory tests. Blood samples were collected before treatment and after 30 and 60 days of treatment.RESULTS: Adverse reactions were reported in 28 patients (87.5%) patients and the most frequent of these were pruritus (50%), prickling (43.8%), muscle weakness (37.5%) and skin rash (31.3%). Out of the 28 patients with adverse reactions, eight (28.57%) discontinued their treatment. The adverse reactions that culminated with discontinuation of the treatment were prickling (7; 87.5%) or skin eruptions (5; 62.5%). There was a slight increase in aminotransferase levels during the treatment in 9.4% of the patients.CONCLUSIONS: Following up the drug therapy administered to Chagas patients is of great importance for prevention and early detection of adverse reactions to drugs.

【 授权许可】

Unknown