Influence of acute-phase inflammatory response on serum levels of retinol and retinol binding protein in HIV/AIDS patients

Revista da Sociedade Brasileira de Medicina Tropical

Universidade de São Paulo, Ribeirão Preto¹  Jordão Júnior, Alceu Afonso¹  Neves, Fábio Fernandes¹  Figueiredo, José Fernando de Castro¹  Vannucchi, Hélio¹ 

关键词: Vitamin A;    AIDS;    Retinol;    HIV;    Cytokines;    Inflammatory activity;   

DOI  :  10.1590/S0037-86822010000100006

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

INTRODUCTION: Hyporetinolemia is an independent prognostic factor in AIDS patients. Inflammatory activity causes a reduction in the serum levels of this nutrient in the general population. However, there are no studies assessing the impact of inflammatory activity on the serum retinol level in AIDS patients.METHODS: A cross-sectional assessment was conducted on 41 patients hospitalized due to AIDS complications. Inflammatory markers (C-reactive protein and tumor necrosis factor-alpha) and serum retinol and retinol binding protein concentrations were quantified.RESULTS: Despite the low (14.6%) prevalence of hyporetinolemia, a significant negative correlation was observed between the inflammatory markers and the serum retinol and retinol binding protein levels in AIDS patients.CONCLUSIONS: Acute-phase inflammatory activity is associated with low serum retinol levels in individuals with AIDS.

【 授权许可】

Unknown