Pulmonary changes during acute experimental murine manson schistosomiasis

Revista da Sociedade Brasileira de Medicina Tropical

Souza Neto, Joaquim Pereira de¹  Andrade, Zilton A.¹  Gonçalo Moniz Research Center, Salvador, Brazil¹  Souza, Samaly dos Santos¹ 

关键词: Acute schistosomiasis;    Pneumonitis;    Dyspnea;    Periovular granuloma;   

DOI  :  10.1590/S0037-86822009000100002

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Dry cough, dyspnea and manifestations of bronchial asthma have recently been observed in patients with acute schistosomiasis. To investigate the type and pathogenesis of these conditions, an experimental mouse model for acute schistosomiasis was used. Forty mice were divided into four groups of ten each: three infected groups and a non-infected control group. The animals were examined 7, 28-35 and 40 days after exposure to cercariae. During the acute phase of the infection (28-35 days), a process of multifocal interstitial pneumonitis involving the peribronchial, peribronchiolar and subpleural tissues was found. This process was not seen during the other phases of the infection. Indirect immunofluorescence failed to demonstrate the presence of schistosomal antigens in the acute-phase lesions. The pneumonitis was attributed to products (inflammatory mediators) from acute-phase periovular necrotic-inflammatory lesions in the liver that were transported to the lungs by the bloodstream.

【 授权许可】

Unknown