Chronic Chagas disease patients with sinus node dysfunction: is the presence of IgG antibodies with muscarinic agonist action independent of left ventricular dysfunction?

Revista da Sociedade Brasileira de Medicina Tropical

Medeiros, Aline Silva de¹  Carvalho, Antonio Carlos Campos de¹  Costa, Patrícia Cristina Santos¹  Corrêa Filho, Wilson Braz¹  Pedrosa, Roberto Coury¹  Universidade Federal do Rio de Janeiro, Rio de Janeiro¹  Pereira, Basílio de Bragança¹  Altschüller, Maria Beatriz Corrêa de Mello¹ 

关键词: ChagasÂ’ disease;    Molecular mimicry;    Sinus node dysfunction;    Muscarinic receptors;    Autonomic dysfunction;   

DOI  :  10.1590/S0037-86822007000600014

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Studies have shown that muscarinic agonist IgG antibodies from Chagas disease patients alter the electrical activity of cardiac cells in vitro. Others have considered their presence, along with sinus node dysfunction, to be consequences of progressive cardiac lesions. The aim of this study was to evaluate the relationship between these antibodies and sinus node and left ventricular dysfunction in 65 chronic Chagas disease patients. These patients were divided into group I, composed of 31 patients with sinus node dysfunction, and group II, composed of the patients without this syndrome. Data analysis using the log linear model showed interdependence between sinus node dysfunction and the antibodies (p = 0.0021) and between nodal and ventricular dysfunction (p = 0.0005). However, no relationship was found between the antibodies and ventricular function. Age and sex did not influence any other variables. The chronic Chagas disease patients with sinus node dysfunction had higher prevalence of muscarinic agonist antibodies, independent of the presence of myocardial dysfunction.

【 授权许可】

Unknown