Clinical and ultrasound findings before and after praziquantel treatment among Venezuelan schistosomiasis patients

Revista da Sociedade Brasileira de Medicina Tropical

Ruiz-Guevara, Raiza¹  Universidad Central de Venezuela, Caracas, Venezuela¹  Valero, Sharon Kay¹  Noya, Belkisyolé Alarcón de¹  Lecuna, Pablo¹  Noya, Oscar¹  Garassini, Miguel¹ 

关键词: Schistosoma mansoni;    Ultrasound;    Low transmission area;    Venezuela;    Praziquantel;   

DOI  :  10.1590/S0037-86822007000500003

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Abdominal ultrasound can be a useful tool for diagnosing periportal fibrosis related to Schistosoma mansoni infection, and also for planning and monitoring the evolution of hepatic morbidity following control measures. We evaluated the standardized ultrasound methodology proposed by the World Health Organization for detecting periportal fibrosis and portal hypertension, among patients from an endemic area in Venezuela, and the impact of praziquantel treatment 3-5 years later. After chemotherapy, complete reversal of periportal lesions was observed in 28.2% of the cases and progression of the disease in 5.1%. Improvement in the hepatic disease started with a reduction in the periportal thickening followed by a decrease in the size of the left hepatic lobe, spleen and mesenteric and spleen veins. Ultrasound confirmed the clinical findings after chemotherapy among the patients with reversal of the disease. However, in patients with more advanced disease, these findings were contradictory. There was no correlation between evolution of the disease seen on ultrasound and age, intensity of infection or serological findings.

【 授权许可】

Unknown