Participation of platelets in the process of fibrosis in patients with mansonic schistosomiasis

Revista da Sociedade Brasileira de Medicina Tropical

Fundação Hemominas, Uberaba¹  Soares, Sheila¹  Moraes-Souza, Helio¹  Universidade Federal do Triângulo Mineiro, Uberaba¹  Rodrigues Júnior, Virmondes¹  Silva, David Teixeira Nascimento¹ 

关键词: Mansoni schistosomiasis;    Platelet;    Fibrosis;    P-selectin;    PDGF-AB;    TGFb1;   

DOI  :  10.1590/S0037-86822007000300014

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

The aim of this study was to evaluate platelet activation through P-selectin, and PDGF-AB and TGFb1 content, in schistosomiasis patients who developed fibrosis (F3) and who did not present this (F0), and in a control group (C). The results showed that the percentage of P-selectin in platelets without agonist stimulation was 10.6% in F3, 11.1% in F0 and 6.3% in C. After the addition of ADP/adrenaline, the percentages were 44%, 25.3% and 42%, respectively. The PDGF-AB and TGFb1 contents per platelet were 11,016ng/dl (F3), 3,172ng/dl (F0) and 5.01ng/dl (C) and 0,012ng/dl (F3), 5.27ng/dl (F0) and 4.66ng/dl (C), respectively. Concerning the P-selectin, we can conclude that platelets from patients with schistosomiasis continued to be responsive to agonists, despite being pre-activated. There were no differences in TGFb1 between the groups, but the PDGF-AB content was significantly higher in F3. This suggests that PDGF-AB may have some participation in the development of fibrosis.

【 授权许可】

Unknown