Evaluation of the performance of immunological parameters as indicators for clinical progression of chronic HTLV-1 infection

Revista da Sociedade Brasileira de Medicina Tropical

Catalan-Soares, Bernadete¹  Universidade Federal de Minas Gerais, Belo Horizonte¹  Carneiro-Proietti, Anna Bárbara de Freitas¹  Coelho-dos-Reis, Jordana Grazziela Alves¹  Martins-Filho, Olindo Assis¹  Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina¹  Fundação Centro de Hematologia e Hemoterapia de Minas Gerais, Belo Horizonte¹  Barbosa-Stancioli, Edel Figueiredo¹  Rocha, Roberta Dias Rodrigues¹  Hospital Sarah Kubitschek, Belo Horizonte¹  Brito-Melo, Gustavo Eustáquio Alvim¹  Ribas, João Gabriel¹  Fundação Oswaldo Cruz, Belo Horizonte¹ 

关键词: HTLV-1;    Immunophenotyping;    Performance indices;    Morbidity indicators;   

DOI  :  10.1590/S0037-86822007000100006

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

This study evaluated the performance of single and combined laboratory parameters, B-lymphocyte percentages (%LB), T/B cell ratio and %CD8+HLA-DR+/CD8+, to differentiate asymptomatic cases (AS) from HAM/TSP patients (HT) within a population of HTLV-1 seropositive cases. Percentage indices demonstrated that each parameter alone presented moderate performance, with co-negativity of 83 and 91% for %LB and T/B cell ratio, respectively, and co-positivity of 78% for %CD8+HLA-DR+/CD8+. Combined analysis (%CD8+HLA-DR+/CD8+ and T/B cell ratio) did not show any substantial performance enhancement (co-positivity = 75% and co-negativity = 74%). Likelihood ratio analysis using different value ranges for the separate parameters revealed that HTLV-1 seropositive cases with %LB<7%, T/B cell ratio>11 and %CD8+HLA-DR+/CD8+>70% would have, respectively, 11, 19 and 10 times greater chance of belonging to the HT group. Therefore, use of these phenotypic indicators as complementary laboratory methods for monitoring the clinical progression of chronic HTLV-1 infection is recommended.

【 授权许可】

Unknown