Trends in Haemophilus influenzae type b meningitis in Brazil in children under five years of age from 1983 through 2002

Revista da Sociedade Brasileira de Medicina Tropical

Freitas, Isabel Cristina Martins de¹  Universidade de São Paulo, Ribeirão Preto¹  Moraes, Suzana Alves de¹  Universidade Federal do Triângulo Mineiro, Uberaba¹  Miranzi, Sybelle de Souza Castro¹ 

关键词: Haemophilus influenzae type b;    Bacterial meningitis;    anti-HIB vaccines;    Time-series;   

DOI  :  10.1590/S0037-86822006000500010

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

The study was based on an ecological design using a historical time series (1983-2002), related to Haemophilus influenzae type b meningitis in Brazil. Incidence, mortality and case-fatality rates, as well as trends in incidence and morbidity-mortality were estimated in children less than 5 years of age. Polynomial regression analysis was used to analyze trends, adopting a significance level of 0.05. 43.9% of confirmed cases occurred in infants less than 1 year old and 38.7% in children 1-4 years old. The observed rates were also highest in these two age strata. The incidence and mortality rates showed an increasing trend, until approximately 1999, when a quick decline was observed. The study results reinforce the effectiveness of the Vaccination Program against HIB in Brazil, which benefited age ranges that did not receive the vaccine (Herd Immunity).

【 授权许可】

Unknown