Immunotherapy, immunochemotherapy and chemotherapy for American cutaneous leishmaniasis treatment

Revista da Sociedade Brasileira de Medicina Tropical

Universidade Federal de Minas Gerais, Belo Horizonte¹  Botelho, Ana Cristina de Carvalho¹  Universidade Federal de Ouro Preto, Ouro Preto¹  Batista, Sebastião Mariano¹  Genaro, Odair¹  Nascimento, Evaldo do¹  Dias, Magno¹  Fundação Ataulfo Paiva, Belo Horizonte¹  Lima, Antonio de Oliveira¹  Williams, Paul¹  Mayrink, Wilson¹  Michalick, Marilene Susan Marques¹  Melo, Maria Norma de¹  Ministério da Saúde¹  Costa, Carlos Alberto da¹  Magalhães, Paulo Araújo¹  Machado-Coelho, George Luiz Lins¹  Caiaffa, Waleska Teixeira¹  Fundação Oswaldo Cruz, Belo Horizonte¹ 

关键词: American cutaneous leishmaniasis;    Treatment;    Immunotherapy;   

DOI  :  10.1590/S0037-86822006000100003

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

The first choice of treatment for American cutaneous leishmaniasis is the pentavalent antimonial drug. Although it has been shown that this treatment is mostly effective and indicated, some disadvantages should be taken into account such as side effects, long term treatment inconveniences and counter-indication for patients suffering from cardiopathy, nephropathy; yet, aging, pregnancy and other conditions. With the advent of the vaccine anti-American cutaneous leishmaniasis as a prophylactic measure, studies on therapy using the vaccine associated or not with other drugs have been performed by many investigators and it is currently among the alternative treatments and prevention measures for American cutaneous leishmaniasis. In conclusion, the association between antimony and vaccine (immunochemotherapy) showed the same cure rate when compared with the standard treatment (100%) and it was also able to reduce the salt volume in 17.9% and treatment length from 87 to 62 days, decreasing side effects.

【 授权许可】

Unknown