Clinical and laboratorial alterations in Plasmodium vivax malaria patients and glucose-6-phosphate dehydrogenase deficiency treated with primaquine at 0.50mg/kg/day

Revista da Sociedade Brasileira de Medicina Tropical

Santos, Eliane B.¹  Silva, Mônica C.M.¹  Póvoa, Marinete M.¹  Guerreiro, João F.¹  S. Filho, Manoel G.¹  Universidade Federal do Pará, Belém¹  Costa, Elenild G.¹  Instituto Evandro Chagas, Belém¹  Centro de Ensino Superior do Pará, Belém¹ 

关键词: G6PD Deficiency;    Primaquine;    Malaria;   

DOI  :  10.1590/S0037-86822004000300004

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

The adverse effects of primaquine (0.50mg/kg/day) were investigated in eleven patients with vivax malaria (three patients with glucose-6-phosphate dehydrogenase deficiency). Clinical and laboratorial alterations indicated acute hemolysis in only the enzymopenic patients and treatment was interrupted. Our results suggest that screening for G6PD deficiency should be carried out in patients with vivax malaria infection in order to avoid complications due to primaquine.

【 授权许可】

Unknown