Clinical and immunological consequences of the association between HTLV-1 and strongyloidiasis

Revista da Sociedade Brasileira de Medicina Tropical

Oliveira Júnior, Jamary¹  Universidade Federal da Bahia, Salvador, Brasil¹  Carvalho, Edgar Marcelino¹  Muniz, André¹  Porto, Maria Aurélia F.¹ 

关键词: Strongyloidiasis;    HTLV-1;    Strongyloides stercoralis;   

DOI  :  10.1590/S0037-86822002000600016

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Strongyloidiasis is one of most important forms of helminthiasis in tropical countries and epidemiologic studies have shown the association of this parasitic disease with HTLV. It has been observed in regions where both these agents are endemic and coinfection may result in an increase in the disseminated forms of strongyloidiasis as well as recurrent strongyloidiasis. While HTLV-1 is related to a high production of IFN-g and deviation of the immune response towards a Th1 response, the protection against helminths is associated with Th2 like immune response. Individuals infected with HTLV and S. stercoralis have a reduction in the production of IL-4, IL-5, IL-13 and parasitic IgE response, all of which are factors participating in the defense mechanism against S. stercoralis. These abnormalities are the basis for the occurrence of an increase in the severe forms of strongyloidiasis among patients infected with HTLV-1.

【 授权许可】

Unknown