Antifungal activity of Caryocar brasiliensis (Caryocaraceae) against Cryptococcus neoformans

Revista da Sociedade Brasileira de Medicina Tropical

Ferri, Pedro Henrique¹  Silva, Maria do Rosário Rodrigues¹  Santos, Suzana da Costa¹  Fernandes, Orionalda de Fátima Lisboa¹  Universidade Federal de Goiás, Goiânia¹  Paula, Thaliana de Freitas¹  Garcia, Ana Cristina Ferreira¹  Passos, Xisto Sena¹ 

关键词: Caryocar brasiliensis;    Cerrado plant;    Cryptococcus neoformans;    Antifungal activity;   

DOI  :  10.1590/S0037-86822002000600013

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

The widespread occurrence of cryptococcosis mainly in immunocompromised patients and the side effects of available drugs which are effective against this mycosis have led investigators to search for new antimycotic agents. Caryocar brasiliensis derived compounds were investigated against Cryptococcus neoformans using the agar dilution method. Based on MIC values, the best results were obtained with a concentration of £ 250µg/mL of cuticular waxes of the Caryocar brasiliensis leaf collected during the dry period (170.8mm of precipitation) which inhibited the growth of 91.3% (21/23) Cryptococcus neoformans isolates.

【 授权许可】

Unknown