Presence of human papillomavirus in malignant oral lesions

Revista da Sociedade Brasileira de Medicina Tropical

Spolidório, Luis Carlos¹  Universidade Estadual de São Paulo, Araraquara¹  Reis, Rosana Inácio dos¹  Oliveira, Maria Rita Brancini de¹  Neves, Karina Antunes¹  Malavazi, Iran¹  Zuanon, José Antonio Sampaio¹  Benatti Neto, Carlos¹  Soares, Christiane Pienna¹  Universidade Estadual Paulista, Araraquara¹ 

关键词: Human papillomavirus;    Oral;    Leucoplakia;    Invasive squamous cell carcinoma;    In situ hybridization;   

DOI  :  10.1590/S0037-86822002000500003

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

The purpose of this study was to investigate the prevalence of human papillomavirus 6/11 and 16/18 in patients, with oral lesions clinically diagnosed as leucoplakia, attending the School of Dentistry, University of São Paulo State/UNESP, Brazil. After paraffin embedded process, in the sections staining with H&E, 30 biopsies were screened and separated on 3 groups: 10 oral lesions without dysplasia, 10 with dysplasia, and 10 with invasive squamous cell carcinoma. The lesions with dysplasia were classified in agreement with Van Der Wall's histopathological standard method. Oral lesions were investigated for the presence of human papillomavirus (HPV) by in situ hybridization with wide-spectrum, 6/11 and 16/18 biotinylated probes. HPV 16/18 was found in 20% (n=2) of the leucoplakia with severe-degree dysplasia. The presence of HPV 16/18 in malignant lesions suggests its importance as a risk factor for oral carcinogenesis.

【 授权许可】

Unknown