Reinfections and the development of schistosomal periportal fibrosis in the murine model

Revista da Sociedade Brasileira de Medicina Tropical

Andrade, Zilton A.¹  Souza, Marcia Maria de¹  Santos, Antonio Benigno Araújo¹  Fundação Instituto Oswaldo Cruz, Salvador, Brasil¹ 

关键词: Periportal fibrosis;    Schistosomiasis;    Reinfections;   

DOI  :  10.1590/S0037-86822000000200007

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Experimental pipestem fibrosis of the liver developed more frequently (69.2%) in mice submitted to repeated infections with Schistosoma mansoni, than with single infection (11.1%). The counting of eggs in the liver revealed no significant differences between the two experimental groups. Although the reason why multiple infections favor the development of pipestem fibrosis has not been elucidated, the data obtained represent an experimental support to clinico-epidemiological claims that repeated infections play a role in pathogenesis of hepatosplenic schistosomiasis.

【 授权许可】

Unknown