Cryptocococcus neoformans in patients with AIDS

Revista da Sociedade Brasileira de Medicina Tropical

Costa, Márcio R.¹  Soares, Ailton J.¹  Universidade Federal de Goiás, Goiânia¹  Fernandes, Orionalda de F.L.¹  Costa, Théo R.¹  Pereira, Ana J.S.C.¹  Silva, Maria do Rosário R.¹ 

关键词: Cryptococosis;    Cryptococcus neoformans;    AIDS;   

DOI  :  10.1590/S0037-86822000000100011

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Cryptococcosis is considered the most frequent fungal systemic opportunist infection in patients with AIDS. C. neoformans var. neoformans infects the patients with AIDS more often than C. neoformans var. gattii which has been rarely isolated from patients with AIDS. Even in endemic regions of C. neoformans var. gattii, the variety of neoformans is still the most common agent diagnosed in cryptococcosis of patients with AIDS. Cerebrospinal fluid (CSF) from fifty patients with neurocryptococcosis associated with AIDS were studied. The fungi were isolated in agar Sabouraud medium, and were identified by microscopic and macroscopic examination by agar Sabouraud, agar niger and Christensen's urea medium. The variety was determined based on a color characteristic reaction on glycine-L-canavanina-bromothymol blue agar. From all of the fifty patients' cerebrospinal fluid (CSF) we were able to recover C. neoformans. The isolates were identified as C. neoformans var. neoformans in 47 patients and as C. neoformans var. gattii. in the 3 remaining patients. These findings suggest that both varieties, gattii and neoformans, are agents of neurocryptococcosis in patients with AIDS.

【 授权许可】

Unknown