Problems in the development of a vaccine against schistosomiasis mansoni

Revista da Sociedade Brasileira de Medicina Tropical

Katz, Naftale¹  Centro de Pesquisas René Rachou, Belo Horizonte, Brasil¹ 

关键词: Vaccine;    Schistosomiasis mansoni;    Protection antigens;    Experimental tests;    Clinical tests;   

DOI  :  10.1590/S0037-86821999000600014

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

During the last two decades, studies on antigens that may confer protective immunity to experimental infection with Schistosoma mansoni have made great advances, due largely to increased knowledge in the fields of molecular biology and immunology. Although these studies have made new and important contributions, at the present time the degree of protection conferred remains at approximately 50% in reducing the number of flukes and, with some antigens, the number of eggs. The many questions still to be answered indicate the necessity of carrying out further research on small and large animals before these antigen candidates for vaccines can be used in clinical tests.

【 授权许可】

Unknown