Características físico-químicas do antimoniato de meglumina em diferentes condições de armazenamento

Revista da Sociedade Brasileira de Medicina Tropical

Marsden, Philip Davis¹  Romero, Gustavo Adolfo Sierra¹  Correia, Dalmo¹  Oliveira, Maria Regina Fernandes de¹ 

关键词: Pentavalent antimonial;    Osmolarity;    pH;    Tempera ture of storage;   

DOI  :  10.1590/S0037-86821996000500009

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

During the period October 1992 to July 1995 we measured the osmolarity and pH of ampoules of meglumina antimoniato (glucantime®) from lot 9206L-004 (matiufacturated by Rhodia Farma Ltd, of São Paulo, SP, Brazil) mantained in three temperature conditions namely 4oC, 37oC and ambiental. Although we observed statistically significant differences in osmolarity between samples, the limited number of measurements and the variation of this property in ampoles mantained at the same temperature were obstacles to obtain definitive conclusions. Such a variation was not found with pH. Assuming these parameters could reflect structural changes in the pentavalent antimony molecule, clearly further better controlled experiments are indicated.

【 授权许可】

Unknown