Quimioprofilaxia da malária com mefloquina na amazônia brasileira

Revista da Sociedade Brasileira de Medicina Tropical

Prata, Aluízio¹  Santos, João Barberino¹  Wanssa, Eduardo¹ 

关键词: Malaria;    Mefloquine;    Chemoprophylaxis;   

DOI  :  10.1590/S0037-86821993000300005

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

In a randomised double blind study 122 volunteers living in an endemic malarious area in Amazonian Rondonia State were divided into 4 groups to study malaria supression. The first group received 500mg of mefloquine every month, group II 250mg every two weeks, group III a tablet of Fansidar (500mg sulphadoxine + 25mg pyrimethamine) a week and group IVplacebo. Acute attacks of malaria occured in one individual in group I, 2 subject in group II, and 6 individuals in groups 111 e IV. Protection with mefloquine was significant compared with the placebo group. Both treatment regimens with mefloquine were effective supressants in an area of high prevalence of drug multiresistant Plasmodium falciparum transmission.

【 授权许可】

Unknown