Trypanosoma cruzi and experimental Chagas' disease: characterization of a stock isolated from a patient with associated digestive and cardiac form

Revista da Sociedade Brasileira de Medicina Tropical

Oliveira, E.C.¹  Vêncio, E.F.¹  Luquetti, A.O.¹  Rezende, J.M.¹  Souza, C.¹  Stefani, M.M.A.¹  Moreira, M.A.R.¹ 

关键词: Trypanosoma cruzi strain;    Chagas'disease;    Experimental infection;    Serology;    Histopathology;   

DOI  :  10.1590/S0037-86821993000100006

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

A new Trypanosoma cruzi stock isolated from a patient in the chronic phase of Chagas' disease with the digestive and cardiac fortn of the disease was characterized by experimental infection in isogenic, susceptible, A/Sn strain mice. Parasitemia curves showed up to 1.7x106 parasites/ml and no mortality was observed up to 300 days post infection. Specific IgM was found in mice in the acute phase up to 40 days and also in the chronic phase. IgG antibodies yvere detected in the acute and chronic phase. Histopathology examination demonstrated myotropism to the digestive tract muscle layers and to the heart.

【 授权许可】

Unknown