Effects of levamisole on experimental infections by Plasmodium berghei in mice

Revista da Sociedade Brasileira de Medicina Tropical

Melendez C., Enrique¹  Universidade Federal de Minas Gerais, Belo Horizonte, Brasil¹  Univerdad Centro Occidental Lisandro Alvarado, Barquisimeto, Venezuela¹  Krettli, Antoniana U.¹ 

关键词: Malaria;    Plasmodium berghei;    Chloroquine-resistant strain;    Levamisole;    Immunostimulation;   

DOI  :  10.1590/S0037-86821987000400002

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Levamisole (phenylimidothiazol), considered a strong immunostimulant, when administered to healthy Swiss mice did not cause a significant increase in -the weight of their thymus, liver and spleen, even though the drug was used at different times before removing such organs. High doses ofdrug used in the 4-day prophylactic scheme had no antimalarial effect. However, when given to malaria infected mice 24 hours before, at the same time, and 24 hours after the inoculation of a chloroquine-sensitive or a chloroquine-resistant strain of Plasmodium berghei small doses of the drug induced a somewhat decreased parasitemia, the dose of 1 mg/kg body weight before the inoculum being the best scheme. The mortality rates by malaria in the levamisole treated groups were also delayed although all mice finally died. The data suggest that levamisole may display a stimulant effect on the depressed immune response caused by malaria.

【 授权许可】

Unknown