Host Receptor Immunomodulation in Response to Shigella Surface Antigens: An Insight for Vaccine Development | Science Publications

American Journal of Immunology

Dipak K. Hens¹  Dhira Rani Saha¹  Fahmida Jahan¹  Rushita A. Bagchi¹  Pragna H. Parikh¹  Ashim K. Bagchi¹ 

关键词: Shigella;    Surface Antigens;    Host Cell Receptors;    Immunomodulation;    Immune Response;   

DOI  :  10.3844/ajisp.2015.33.47

学科分类：过敏症与临床免疫学

来源: Science Publications

【 摘 要 】

Shigellosis,caused by Shigella is the most common cause of bacillary dysentery. Thedisease is associated with high morbidity and mortality rate owing to itsmultiple drug resistance. Hence recovery from the disease would primarilydepend on the development of an effective immune-modulator for strong mucosalimmune response. The role of cellular immunity may be a critical factor inprotection against shigellosis as Shigella remains an intracellularpathogen during most of its life-cycle. Development of a potent immunomodulatormay provide strong and long-lasting immunity to shigellosis. In this review, wehave attempted to highlight the disease dimension and its deviation due to theeffect of various Shigella surface antigens that would help in thedevelopment of an effective immune response. Cellular innate immune modulation will be a new generation target forthe development of mucosal candidate vaccines where proper receptor activationsuch as Toll-Like Receptors (TLRs), Cytokine Receptors (CyRs) and/or T-CellReceptors (TCRs) on the host cell could be aimed at producing mucosal immunity.An effort has beenmade to better understand the effect of these immunomodulators againstshigellosis by way of modulating the host immune mechanism to Shigellaouter membrane component.

【 授权许可】

Unknown