Effects of Two Different Dose Levels of Irradiation on Thioredoxin Reductase in the Kidney of Guinea Pigs | Science Publications

American Journal of Immunology

Meltem Nalca Andrieu¹  Ayse H?csonmez¹  Aysen Dizman¹  Ferhan Kömürcü¹  Nedret K?l?c¹  Yildiz Guney¹  Ummuhani Ozel Turkcu¹  Melike Erol¹ 

关键词: Irradiation;    thioredoxin reductase;    kidney;    guinea pigs;   

DOI  :  10.3844/ajisp.2006.58.60

学科分类：过敏症与临床免疫学

来源: Science Publications

【 摘 要 】

It is aimed to examine the state of the oxidant-antioxidant system in the liver of guinea pig caused by ionizing radiation at two different dose levels in the early period. The research was carried out on guinea pigs irradiated with the doses of 8 Gy (group 2) or 15 Gy (group 3) (single dose/whole body) in comparison with control group (group 1). The levels of thioredoxin reductase (TR) in the kidney was measured. The results obtained by non-irradiated and irradiated (8 Gy and 15 Gy) kidneys on guinea pigs indicated that; in 8-15 Gy irradiated animal kidneys TR activity elevated significantly (p<0.001) when compared to the controls, but there was no difference between 8 Gy and 15 Gy irradiated animal groups. The data have shown that gamma-irradiation results in significant increase in TR activity at two different dose levels.

【 授权许可】

Unknown