The Effects of Aerobic Exercise on NF-κB and TNF-α in Lung Tissue of Male Rat

Novelty in Biomedicine

Behzad Behzad Pakrad¹  Hasan Asilian Mahabadi⁴  Sajad Rezaei¹  Hamid Agha-Alinejad³  Batul Rezaei¹  Mohamad Fashi² 

[1] Department of Physical Education & Sports Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran;Ph.D Candidate of Exercise Physiology, Department of Physical Education & Sports Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran.;Associate Professor of Exercise Physiology, Department of Physical Education & Sports Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran.;Associate Professor, Department of Occupational Health Engineering, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

关键词: aerobic exercise;    inflammation;    lung tissue;   

DOI  :  

学科分类：生物科学（综合）

来源: Shahid Beheshti University of Medical Sciences

【 摘 要 】

Background: Regular aerobic exercise improves theBackground: Regular aerobic exercise improves the inflammatory status in different lung diseases. However, the effects of long-term aerobic exercise on the lung response have not been investigated. The present study evaluated the effect of aerobic exercise on the lung inflammatory. Materials and Methods:12 adult male Wistar rats were divided to 2 groups: A: control (n=6), B: aerobic exercise (five times per week for 4 week; n=6). The gene expression of NF-κB and TNF-α were analyzed in lung tissue by Real time–PCR. In order to determine the significant differences between groups independent t-test were used. Results:Aerobic exercise inhibited the gene expression of NF-κB and TNF-α. But there was no significant difference between A and B groups for TNF-α and NF-κB. Conclusion:We conclude that four week aerobic exercise decrease inflammatory status in lung tissue. Our results indicate a need for human studies that evaluate the lung responses to aerobic exercise.

【 授权许可】

Unknown