Studying Effects of Gold Nanoparticle on Dose Enhancement in Megavoltage Radiation

Journal of Biomedical Physics and Engineering

Gh Ataei⁴  M Mahdavi³  S R Mahdavi¹  M Khadem Abolfazli² 

[1] Iran Medical university;Babol medical university;Mazandaran university;Babol Medical university

关键词: MCNPX Code;    Megavoltage Radiotherapy;    Gold Nanoparticle;    Dose Enhancement;   

DOI  :  

学科分类：生物科学（综合）

来源: Shiraz University of Medical Sciences

【 摘 要 】

Background:Gold nanoparticles are emerging as promising agents for cancer therapy and are being investigated as drug carriers, photothermal agents, contrast agents and radiosensitisers. Objective:The aim of this study is to understand characteristics of secondary electrons generated from interaction of gold nanoparticles GNPs with x-rays as a function of nanoparticle size and beam energy and thereby further understanding of GNP-enhanced radiotherapy.Methods:Effective range, defection angle, dose deposition, energy, and interaction processes of electrons produced from the interaction of x-rays with a GNP were calculated by Monte Carlo simulations. The MCNPX code was used to simulate and track electrons generated from 30 and 50 nm diameter GNP when it is irradiated with a cobalt-60 and 6MV photon and electron beam in water.Results:When a GNP was present, depending on beam types used, secondary electron production increased by 10- to 2000-fold compared to absence of a GNP.Conclusion:GNPs with larger diameters also contributed to more doses .

【 授权许可】

Unknown