Journal of Dental Research, Dental Clinics, Dental Prospects | |
Subcutaneous connective tissue reactions to various endodontic biomaterials: an animal study | |
Mohammad Ali Saghiri1  Franklin Garcia-Godoy1  Dariush Amanat1  Nader Tanideh1  Kasra Karamifar1  Mehrdad Lotfi1  | |
关键词: Bioaggregate; biocompatibility; endodontic cement; Geristore; mineral trioxide aggregate; | |
DOI : | |
学科分类:农业科学(综合) | |
来源: Tabriz University of Medical Sciences * Faculty of Dentistry | |
【 摘 要 】
Background and aims. Biocompatibility of root-end filling materials is a matter of debate. The aim of this study was to compare the biocompatibility of a variety of commercial ProRoot WMTA cements and a resin-based cement (Geristore®) with different pH values of setting reaction and different aluminum contents, implanted into the subcutaneous connective tissue of rats at various time intervals.Materials and methods. Fifty Sprague-Dawley rats were used in this study. Polyethylene tubes were filled with Angelus WMTA, ProRoot WMTA, Bioaggregate, and Geristore. Empty control tubes were implanted into subcutaneous tissues and harvested at 7-, 14-, 28- and 60-day intervals. Tissue sections of 5 μm were stained with hematoxylin and eosin and observed under a light microscope. Inflammatory reactions were categorized as 0, none (without inflammatory cells); 1, mild (inflammatory cells ≤25); 2, moderate (25–125 inflammatory cells); and 3, severe (>125 inflammatory cells). Statistical analysis was performed with Kruskal-Wallis and Mann Whitney U tests.Results. ProRoot WMTA and Angelus elicited significantly less inflammation than other materials (P< 0.05). After 7 days, however, all the materials induced significantly more inflammation than the controls (P< 0.05). Angelus-MTA group exhibited no significant differences from the Bioaggregate group (P=0.15); however, ProRoot WMTA elicited significantly less inflammation than Bioaggregate (P=0.02). Geristore induced significantly more inflammation than other groups (P< 0.05).Conclusion. Geristore induced an inflammatory response higher than ProRoot WMTA; therefore, it is not recommended for clinical use.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912010158722ZK.pdf | 1486KB | download |