Larvicidal activity of Ramalina usnea lichen against Aedes aegypti

Revista Brasileira de Farmacognosia

Braz-Filho, Raimundo¹  Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Brazil¹  Vieira, Ivo J.C.¹  Instituto Federal Fluminense, Campos dos Goytacazes, Brazil¹  Faculdade de Medicina de Campos, Brazil¹  Moreira, Antônio S.N.¹  Fernandes, Roberta O.S.¹  Lemos, Francisco J.A.¹ 

关键词:  Larvicidal activity;    Lichenized fungi;    Ramalina usnea;    Aedes aegypti;   

DOI  :  10.1016/j.bjp.2016.03.006

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

The larvicidal activity of the methanol extract, fractions and compounds 2-hydroxy-4-methoxy-6-propyl-methyl benzoate and (+)-usnic acid identified from the lichen Ramalina usnea (L.) R. Howe, Ramalinaceae, was tested against the third instar larvae of the Aedes aegypti mosquito. The methanol extract and three fractions showed activity, killing 100% and 96.6% of the larvae at a concentration of 150 µg/ml at 24 h. The isolated compounds, 2-hydroxy-4-methoxy-6-propyl-methyl benzoate and the (+)-usnic acid showed larvicidal activity, presenting LC50 values of 4.85 and 4.48 µg/ml, respectively. This is the first study of its kind reporting the larvicidal activity against the A. aegypti mosquito with compound (1).

【 授权许可】

Unknown