Pyrimidine alkaloids from Eudistoma vannamei

Revista Brasileira de Farmacognosia

Basso, Thiago Olitta¹  Universidade Federal de São Paulo, Santos, Brazil¹  Universidade de São Paulo, Ribeirão Preto, Brazil¹  Universidade Federal do Amazonas, Itacoatiara, Brazil¹  Lopes, Norberto Peporine¹  Universidade Federal do Ceará, Fortaleza, Brazil¹  Takeara, Renata¹  Lopes, João Luis Callegari¹  Jimenez, Paula Christine¹  Universidade de São Paulo, São Paulo, Brazil¹  Costa-Lotufo, Letícia Veras¹ 

关键词:  Pyrimidine;    Tunicate;    Steroids;    Nucleosides;   

DOI  :  10.1016/j.bjp.2015.08.001

来源: Sociedade Brasileira de Farmacognosia

【 摘 要 】

Methanolic extracts of the Brazilian endemic ascidian Eudistoma vannamei have been extensively studied for their cytotoxic activity against several human cancer cell lines. Previous work reported the occurrence of purine derivatives and staurosporine alkaloids as the major nitrogen-containing compounds. In this study, we report the occurrence of three pyrimidine alkaloids in addition to cholesterol, sitosterol and stigmasterol.

【 授权许可】

Unknown